Molecular characterization of group B streptococci with reduced penicillin susceptibility recurrently isolated from a sacral decubitus ulcer

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First molecular characterization of group B streptococci with reduced penicillin susceptibility.

Group B streptococci (GBS; Streptococcus agalactiae) are the leading cause of neonatal invasive diseases and are also important pathogens for adults. Penicillins are the drugs of first choice for the treatment of GBS infections, since GBS have been regarded to be uniformly susceptible to penicillins so far. Here we characterize the first strains of GBS with reduced penicillin susceptibility (PR...

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Genetic heterogeneity in pbp genes among clinically isolated group B Streptococci with reduced penicillin susceptibility.

The recent emergence of group B streptococcal isolates exhibiting increased penicillin MICs at the Funabashi Municipal Medical Center and other hospitals in Japan prompted a comparative analysis of the penicillin-binding proteins (PBPs) from those strains with the PBPs from penicillin-susceptible strains comprising four neonatal invasive strains isolated from 1976 to 1988 and two recent isolate...

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Analysis of multidrug resistant group B streptococci with reduced penicillin susceptibility forming small, less hemolytic colonies

Group B streptococci (GBS; Streptococcus agalactiae) are the leading cause of neonatal invasive diseases and are also important pathogens for elderly adults. Until now, nearly all GBS with reduced penicillin susceptibility (PRGBS) have shown β-hemolytic activity and grow on sheep blood agar. However, we have previously reported three PRGBS clinical isolates harboring a CylK deletion that form s...

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Group B streptococcal necrotizing fasciitis from a decubitus ulcer

A 29-year-old man with paraplegia secondary to a gunshot wound presented to the emergency department (ED) with worsening abdominal pain over the past 2 weeks with associated fever, dysuria, nausea, and vomiting. He had been diagnosed with a urinary tract infection (UTI) 2 days earlier and was started on antibiotics without improvement. On examination he was afebrile, tachycardic up to 140, tach...

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Pneumorrhachis Secondary to a Sacral Decubitus Ulcer

An elderly woman with a chronic decubitus sacral ulcer presented to the emergency department with sepsis. A computed tomography of her abdomen showed diffuse gas extending throughout the thoracolumbar spinal canal. Pneumorrhachis is a rare radiographic finding defined as gas within the spinal canal. There are many causes of pneumorrhachis ranging from trauma to infection. In this case the pneum...

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ژورنال

عنوان ژورنال: Journal of Antimicrobial Chemotherapy

سال: 2009

ISSN: 0305-7453,1460-2091

DOI: 10.1093/jac/dkp374